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Saturday, August 25, 2012
John Mayer Dumps Katy Perry
Well, he has done it again folks. The legendary John Mayer has bedded and dumped the Teen Dream, Katy Perry. Uggh, dude makes me sick! Radar Online claims that John pursued Katy till she finally caved. I am sure he is charming – I mean he has dated top women of Hollywood; Jennifer Aniston, Jennifer Love Hewitt, Jessica Simpson, Minka Kelly, Taylor Swift, and he was even rumored to have an affair with Food Networks Giada De Laurentiis. Dude gets around. But Katy tried to be strong, “She held off from his advances for the longest time, but he laid on the charm thick and promised her he was a changed man. She eventually gave in, fell head over heels for him and then ? yep ? once he had made his conquest, he dumped her.? According to Us Weekly: ?She?s really upset about it. She is making it seem like it wasn?t serious with John, but she is hurt.? So freaking sad. I mean every girl has been through it, and it sucks. It is too bad. I don;t get what John is looking for. He is aiming to be the next George Clooney, except he isn’t doing it [...]
Streamline Your Travel Experience ? Quickly Connect With Gogo?s iPhone Application
We love saving time here at Points, Miles & Martinis. Our travel style is close to the real Ryan Bingham, we never, ever check a bag, pack light, and look for opportunities to streamline our travel experience at every corner. Thankfully the team at Gogo has helped us shave a few moments of down time during our travel experience with their Gogo iPhone application.
Using the Gogo iPhone application will have you quickly connected and surfing the web in no time. There are only a few simple steps the Gogo application takes to get you connected.
Automatically Connect With The Gogo iPhone Application
The application automatically begins to try to connect you to the web when you open the application. Sit back and relax while Gogo does all the work. How awesome is that?
If you forgot to select your network or jumped the gun like I did, you?ll receive a polite message letting you know you didn?t select a network or that your plane isn?t up to 10,000 feet yet.
After a few moments you?ll be rocking and rolling with a Gogo connection. But just one more step before you can start surfing as you climb through the sky to cruising altitude.
Enter a few characters to validate your wifi signal.
Now you?re in and can start surfing the web as you prepare to order your favorite free cocktail in the sky.
Bottom Line
The Gogo iPhone application will save you time by getting you connected faster so you can surf the web and catch up on your favorite [Boarding Boarding] blog(s).
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Friday, August 24, 2012
New insights to the function of molecular chaperones
ScienceDaily (Aug. 24, 2012) ? Heidelberg molecular biologists have gained new insights into the function of so-called molecular chaperones in protein synthesis. The team headed by Dr. G?nter Kramer and Prof. Dr. Bernd Bukau of the DKFZ-ZMBH Alliance, a research association between Heidelberg University's Center for Molecular Biology (ZMBH) and the German Cancer Research Center (DKFZ), was able to demonstrate how a molecular chaperone in bacterial cells can influence the formation of the three-dimensional structure of new proteins.
"Our findings have put an end to a scientific controversy about the point in time within protein synthesis at which the folding of a protein into a defined three-dimensional structure begins and the roles played by individual factors involved in the process," says Prof. Bukau. The research findings have been published as an online article in Molecular Cell and are to appear in the journal's print version as well.
Proteins are produced by ribosomes, large molecular machines translating genetic information into long chains of amino acids. But these so-called polypeptide chains only turn into functional proteins after they have been folded into stable three-dimensional structures. Incorrectly folded proteins can have devastating effects on cells or even the whole organism. Examples are neurodegenerative disorders like Alzheimer's disease or Parkinson's disease. To prevent folding defects, cells have whole arsenals of folding assistants referred to as molecular chaperones. Some chaperones support folding during protein synthesis at the ribosome. Up to now, the precise details of this complex process were largely unknown.
The Heidelberg molecular biologists have now succeeded in supplying a more exact description of a chaperone called Trigger Factor from the bacterium Escherichia coli. To this end, all the components required for protein synthesis were isolated from bacterial cells and the protein folding process was observed during synthesis in the test tube. "It turned out that in the beginning of synthesis the growing polypeptide chain is prevented from folding by its spatial proximity to the ribosome," says Dr. Kramer. "This inhibition is reduced in the course of synthesis by the fact that the already synthesised parts of the growing chain are increasingly moved away from the ribosome by the addition of new amino acids." Trigger Factor prolongs the effect of the ribosome and also interferes with folding. In the course of translation it binds to the ribosome and the growing polypeptide chain, thus also preventing the folding of parts of the protein already further away from the ribosome. Accordingly, the ribosome and Trigger Factor act in concert to confine premature folding of the nascent polypeptide.
"The surprising thing is," says Dr. Kramer, "that Trigger Factor can also unfold parts of the protein." This activity of Trigger Factor can reverse premature folding attempts of the growing polypeptide chain and facilitate a new folding attempt if the earlier one was unsuccessful. "The essential point is that Trigger Factor only develops unfolding activity when it is attached to the ribosome. In other words, it cannot unfold fully synthesised proteins."
In conjunction with other findings produced by the Heidelberg research team, these new discoveries now represent an extended model of the molecular mechanism of protein folding. At the early stage of protein synthesis, the ribosome prevents premature folding of the growing polypeptide chain. Other important modifications to the protein chain have to be performed here as well. Trigger Factor is not involved at this stage. The binding of Trigger Factor keeps the growing polypeptide chain unfolded until sufficiently large parts of the protein are synthesised so that productive folding can take place. But if the protein has already undertaken premature folding steps when Trigger Factor binds, these steps can be reversed by the unfolding activity of Trigger Factor. In this way the formation of harmful proteins in the cell can be actively prevented. "These findings represent an important advance towards a more detailed understanding of the conversion of genetic information into functioning proteins," says Prof. Bukau. "This process is indispensable for the survival of every cell and every organism."
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The above story is reprinted from materials provided by Heidelberg, Universit?t.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Anja Hoffmann, Annemarie?H. Becker, Beate Zachmann-Brand, Elke Deuerling, Bernd Bukau, G?nter Kramer. Concerted Action of the Ribosome and the Associated Chaperone Trigger Factor Confines Nascent Polypeptide Folding. Molecular Cell, 2012; DOI: 10.1016/j.molcel.2012.07.018
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/g7UndJwfFGI/120824082511.htm
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GWH News and Notes: August 23 Global Championship Wrestling ...
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Source: http://www.gwhnews.com/2012/08/august-23-global-championship-wrestling.html
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Program Yourself Thin, Health & Fitness
Court: Texas Can Ban Planned Parenthood From Women's Health Program
A federal appeals court on Tuesday lifted a temporary injunction and ruled that Texas can remove Planned Parenthood from the Women's Health Program.
Court: Texas Can Cut Women's Health Program Funding to Planned Parenthood
According to Fox News, the 5th U.S. Circuit Court of Appeals in New Orleans has declined to impose an injunction against the state of Texas' plan to cut off funding to Planned Parenthood under the Women's Health Program.
Maternal & Family Health Services Announces WIC Nutrition Program Expands Income Guidelines
Maternal and Family Health Services announces that the Women, Infants and Children (WIC) Nutrition Program has expanded income guidelines allowing more families to participate in the free nutrition education program. WIC is the nation?s premier public health and nutrition education program with an overall goal to influence lifetime nutrition through positive health behaviors. Maternal and Family ...
Court rules Texas can ban Planned Parenthood from health program
A federal court has ruled in favor of Texas, which wants to ban state funding for Planned Parenthood affiliates participating in a health program for low-income women because the family planning network performs abortions.
Health Systems International Named One of 40 "Healthcare's Hottest"
INDIANAPOLIS, IN-- - Health Systems International recently received Modern Healthcare's "Healthcare's Hottest" Award. The program honors 40 fast-growing US-based healthcare companies that posted ...
Missoula, Yellowstone counties offer home health program for moms
Missoula and Yellowstone counties are teaming up to offer a nationally successful home health program for low-income, first-time mothers.
Donations Allow Planned Parenthood to Expand Breast Health Program
Planned Parenthood announced it will expand several of its breast health programs across the country after being bolstered by donations sparked by the Susan G. Komen for the Cure controversy earlier this year.
HealthPartners Fosters "Culture of Health" with Innovative Program Utilizing Ergotron Sit-Stand Solutions
MINNEAPOLIS, Aug. 21, 2012 /PRNewswire/ -- As part of its mission to foster a "culture of health" with employees, Twin Cities-based HealthPartners has implemented an innovative wellness program ...
Magellan Behavioral Health Selected to Administer Military & Family Life Counseling Program for U.S. Department of ...
Magellan Health Services Inc. announced today that its subsidiary, Magellan Behavioral Health Inc., has entered into a contract with the U.S. Department of the Interior on behalf of the U.S.
Gorman Health Group Initiates Offsite Virtual Audit Program
WASHINGTON -- Gorman Health Group (GHG), the leading solutions provider in Government health care programs, announces today its first client to contract for its offsite virtual audit program. The first ...
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Thursday, August 23, 2012
Five things to do when buying a home in Wisconsin | Wisconsin ...
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Read the full article about the five things to do when buying a home ?as reported in RIS Media. Here is a summary?and some additional commentary on the article:
5 DO?s
1. DO take time to know your credit score?? it may get you a better mortgage rate. By learning your credit score, you can also see how you are doing in managing your finances.? Free credits reports are available all over the internet.
2. DO explore mortgage preapproval before you start looking for homes.You?ll know what you can afford and not waste time looking at what you can?t. A preapproval also shows you are a serious buyer
3. DO start off with profesional help.? Your Realtor can help you with number 1 and 2 above as well as make your home search easier by?sending you new listings via email that match your criteria.? A good Realtor keeps their eyes peeled for what their customers are looking for. You don?t have to do all the work yourself.? Consider signing a Buyer Agent agreement for the best representation.
4. DO anticipate your future needs.? How long do you plan to stay in the property? Will it work for you 5 years from now? People move often for lifestyle reasons so keep your changing lifestyle in mind.
5. DO set priorities on what you are looking for in a property?? but separate them into the ?Must-Have features? and the ?Nice to Have, but not imperative? features. It is possible that no house will have absolutely everything you need and want and you will need to decide what is most important.
Happy house hunting! Let us know if we can help in anyway.
Thanks for reading the First Weber Wisconsin real estate & Wisconsin living blog for information on five things to do when buying a home in Wisconsin. ?For additional information for homebuyers in Wisconsin, please see our home buying section on firstweber.com or our home buyer category on this blog. To search for real estate for sale in Wisconsin, please visit firstweber.com
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photo credit?http://www.flickr.com/photos/judy-van-der-velden/7005544517/
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It's Harder to Find Breast Cancer in Dense Breasts, But Does Not ...
Photo by American College of Radiology/Associated Press, via Washington Post
This is good news! While it is harder to detect breast cancer in dense breasts, research is showing that having dense breasts does not decrease your chances of surviving the disease.
Monday, scientists reported a bit of good news about yet another question: Do denser breasts also signal a worse chance of survival? A National Cancer Institute study tracked more than 9,000 breast cancer patients and concluded those with very dense breasts were no more likely to die than similar patients whose breasts weren?t as dense.
?It?s definitely reassuring,? said NCI lead researcher Dr. Gretchen Gierach, who reported the results in the Journal of the National Cancer Institute.
Yes, tumors might be found later in the most dense breasts, but once diagnosed they apparently weren?t more aggressive or harder to treat, explained co-author Dr. Karla Kerlikowske of the University of California, San Francisco, who has long studied breast density.
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via?www.google.com by?Washington Post //?Read More?>>
Several states have now passed laws requiring doctors to notify patients after a mammogram if they have dense breasts. Whether that is a law in your state or not, make sure to talk to your doctor about your mammogram results. Women with dense breasts may need to undergo additional to make sure there are no abnormalities present.
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